What is the Origin of DHEA Brain Protection?

This concept emerged from research in neuroendocrinology that identified DHEA's synthesis and action within the brain, independent of peripheral endocrine glands. The term 'protection' emphasizes its role as an endogenous defense mechanism against various neurological insults. Its study is central to understanding the neurobiological impact of adrenal and gonadal aging.

What is the Mechanism of DHEA Brain Protection?

DHEA exerts its protective effect by acting as an indirect antagonist to the detrimental effects of excessive glucocorticoids, such as cortisol, on the hippocampus. It also directly interacts with NMDA receptors, promoting synaptic plasticity at physiological concentrations, while also possessing antioxidant properties that neutralize reactive oxygen species. This dual action helps to preserve mitochondrial function and maintain the structural scaffolding of neural networks.

DHEA Brain Protection ∞ Area

DHEA Brain Protection

Meaning

DHEA Brain Protection describes the multifaceted neuroprotective actions of Dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, within the central nervous system. As a primary neurosteroid, DHEA works to counteract neuroinflammation, modulate neurotransmitter receptors, and support the structural integrity of neurons. This protective role is particularly significant in mitigating age-related neuronal vulnerability and cognitive decline.