What is the Origin of DHEA Brain Effects?

DHEA was first isolated in the 1930s, but the recognition of its significant role within the brain, independent of peripheral endocrine function, developed with the concept of neurosteroids in the late 20th century. The brain itself synthesizes DHEA, establishing its dual role as both an adrenal steroid and a local paracrine regulator of neuronal activity. This understanding highlights the intricate hormonal-neurological crosstalk.

What is the Mechanism of DHEA Brain Effects?

DHEA exerts its influence by interacting with multiple receptor systems in the brain, notably acting as a positive allosteric modulator of the GABA-A receptor, which contributes to anxiolytic and calming effects. Additionally, DHEA and its metabolites interact with NMDA receptors, playing a role in synaptic plasticity and memory formation. The hormone also exhibits anti-inflammatory properties within the neural tissue, helping to mitigate oxidative stress and preserve neuronal integrity.

DHEA Brain Effects

Meaning

The collective neurological and psychological impacts exerted by Dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S), which function as neurosteroids in the central nervous system. These effects encompass modulation of mood, memory, and stress response, acting independently of or as precursors to sex hormones like testosterone and estrogen. DHEA is recognized clinically for its neuroprotective and neuromodulatory roles, particularly in contexts of age-related cognitive changes.