What is the Meaning of DHEA Balance?

DHEA balance refers to the maintenance of optimal and appropriate circulating levels and metabolic ratios of Dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, relative to an individual's age, sex, and overall hormonal milieu. DHEA, the most abundant circulating steroid, serves as a crucial precursor for the synthesis of androgens and estrogens in peripheral tissues. Achieving DHEA balance is essential for supporting energy levels, immune function, bone density, and neurological health, as its levels naturally decline with age. Clinical evaluation considers the DHEA-S level as a primary marker of adrenal androgen production.

What is the Origin of DHEA Balance?

DHEA is an acronym for Dehydroepiandrosterone. The concept of "balance" is central to endocrinology, emphasizing the homeostatic state where a hormone's production, conversion, and clearance are in equilibrium. As DHEA is produced primarily by the adrenal cortex and declines with the adrenopause, maintaining its balance has become a focus in anti-aging and wellness medicine.

What is the Mechanism of DHEA Balance?

DHEA acts as a prohormone, meaning it is biologically active but primarily serves as a reservoir for downstream steroid synthesis in various peripheral tissues, a process termed intracrinology. The balance is maintained by the rate of its adrenal production, which is regulated by ACTH, and its conversion by sulfotransferases into DHEA-S, which extends its half-life. The subsequent conversion to potent androgens and estrogens is tissue-specific, allowing DHEA to exert pleiotropic effects on different organ systems, supporting both anabolic and neuroprotective functions.

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DHEA Balance

Meaning

Origin

Mechanism

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How Do Lifestyle Factors Influence Adrenal Markers?

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