What is the Origin of DHEA Anti-Inflammation?

This term combines the abbreviation for the hormone DHEA with the biological function of anti-inflammation. DHEA itself is a precursor steroid primarily synthesized in the adrenal cortex, and its anti-inflammatory role has been a subject of research in immunology and endocrinology since its discovery. The concept highlights the immunomodulatory role of adrenal hormones beyond the classical glucocorticoid effects.

What is the Mechanism of DHEA Anti-Inflammation?

DHEA achieves its anti-inflammatory effects through multiple molecular pathways. It can directly suppress the production of pro-inflammatory cytokines, such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), by various immune cells. Additionally, DHEA may influence the balance between T-helper 1 (Th1) and T-helper 2 (Th2) immune responses, favoring a less inflammatory profile. This steroid also serves as a precursor to sex hormones, which themselves possess potent immunomodulatory properties, thereby indirectly contributing to the overall anti-inflammatory milieu.

DHEA Anti-Inflammation ∞ Area

DHEA Anti-Inflammation

Meaning

DHEA Anti-Inflammation refers to the documented biological property of the adrenal steroid dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, to exert counter-regulatory effects against chronic, low-grade systemic inflammation. This action is distinct from the primary role of cortisol but is integral to the overall balance of the HPA axis and the body’s immunological homeostasis. Maintaining adequate DHEA levels is considered a protective factor against age-related inflammatory decline, often termed “inflammaging.”