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DHEA and Pregnenolone

Meaning

Dehydroepiandrosterone (DHEA) and Pregnenolone are foundational, crucial endogenous steroid hormones synthesized primarily within the adrenal glands and, to a lesser extent, in the gonads and the brain, serving as the immediate upstream building blocks for nearly all other essential steroid hormones. Pregnenolone is directly synthesized from cholesterol and acts as the immediate precursor to DHEA, progesterone, and other critical downstream hormones in the complex steroidogenesis cascade. DHEA is recognized as a primary precursor to the potent androgens and estrogens, exerting a wide range of biological effects on immune system function, neurological health, and systemic metabolic balance.