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DHEA Adrenopause

Meaning

DHEA Adrenopause is a clinical term describing the progressive, age-related decline in the production of dehydroepiandrosterone (DHEA) and its sulfated form (DHEA-S) by the adrenal cortex, separate from gonadal senescence. DHEA is a critical precursor to sex hormones like testosterone and estrogen, and its reduction is a notable biological hallmark of aging that begins around the third decade of life. This specific hormonal shift is associated with a decrease in metabolic resilience, mood disturbances, and reduced bone mineral density. Recognizing this distinct pattern allows for targeted, personalized endocrine support strategies.