Question 1

What is the Meaning of DHEA Adrenal Capacity?

Accepted Answer

DHEA adrenal capacity quantifies the adrenal gland's maximal ability to synthesize and secrete dehydroepiandrosterone (DHEA) and its sulfated form, DHEA-S, a key precursor to other sex hormones. This specific measure reflects the functional health and reserve of the adrenal zona reticularis, which is the primary site for androgen synthesis in the adrenals. Clinically, a robust DHEA capacity is associated with markers of vitality, immune function, and neuroprotection, while a significantly reduced capacity can accompany states of chronic stress or advanced biological aging. Assessment of this capacity provides crucial insight into the broader context of steroidogenesis and overall adrenal reserve.

Question 2

What is the Origin of DHEA Adrenal Capacity?

Accepted Answer

The concept is an extension of established adrenal physiology, specifically focusing on the androgenic arm of the complex steroidogenic pathway, which originates in the adrenal cortex. DHEA itself was one of the first adrenal steroids identified, underscoring the gland's critical role beyond glucocorticoid and mineralocorticoid production. The term "capacity" emphasizes the potential functional output of the gland, distinguishing it from simple, static circulating hormone levels.

Question 3

What is the Mechanism of DHEA Adrenal Capacity?

Accepted Answer

DHEA synthesis is regulated primarily by ACTH and involves the enzymatic conversion of pregnenolone, via 17-hydroxypregnenolone, by the key enzyme 17,20-lyase, which is part of the CYP17A1 complex. The measured adrenal capacity is directly dependent on the sustained availability of substrate cholesterol and the optimal, unimpaired activity of these specific steroidogenic enzymes within the zona reticularis. Chronic stress or sustained HPA axis dysregulation can selectively impair this pathway, often leading to a measurable, clinically relevant decline in DHEA output.

DHEA Adrenal Capacity

Meaning

Origin

Mechanism

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