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Detoxification Enzyme Upregulation

Meaning

Detoxification Enzyme Upregulation is the clinical strategy of intentionally increasing the expression and activity of specific enzymes responsible for processing and eliminating endogenous and exogenous toxins. This includes Phase I and Phase II liver detoxification enzymes, such as the cytochrome P450 family and various conjugating enzymes. The goal is to enhance the body’s capacity to neutralize and excrete metabolic byproducts, environmental pollutants, and excess hormones like estrogen metabolites. Optimizing this process is fundamental for maintaining hormonal balance and reducing systemic toxic burden.