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Dermal-Endocrine-Metabolic Axis

Meaning

The Dermal-Endocrine-Metabolic Axis is an integrative physiological model that defines the profound and reciprocal communication pathways linking the skin (dermis), the systemic endocrine system, and the body’s overall metabolic function. This framework recognizes the skin as an active endocrine organ that both produces hormones and expresses receptors for systemic metabolic signals, going far beyond its traditional role as a simple barrier. Dysfunction within this axis can manifest as dermatological conditions, hormonal dysregulation, or features of metabolic syndrome.