What is the Origin of Dermal Androgen Receptors?

The term is derived from "dermal" (skin layer), "androgen" (from Greek andros, meaning man, referring to male sex hormones), and "receptors" (cellular binding sites). This concept is foundational to endocrinology and dermatology, explaining the skin's responsiveness to sex hormones. The presence of these receptors confirms the skin as a primary target organ for androgen action.

What is the Mechanism of Dermal Androgen Receptors?

Upon binding to an androgen, the dermal androgen receptor complex translocates into the cell nucleus, where it interacts with specific DNA sequences known as androgen response elements (AREs). This gene regulation primarily promotes anabolic effects, stimulating dermal fibroblast proliferation and the synthesis of structural proteins like collagen I and III, thereby contributing to dermal thickness and firmness. In sebaceous glands, activation leads to increased lipogenesis and sebum production.

Dermal Androgen Receptors ∞ Area

Dermal Androgen Receptors

Meaning

Specific intracellular protein molecules located within the cells of the dermis, such as fibroblasts and sebocytes, that bind to androgens like testosterone and dihydrotestosterone (DHT) to mediate their biological effects on skin structure and function. These receptors act as ligand-activated transcription factors, directly influencing the expression of genes responsible for regulating collagen production, sebum secretion, and hair follicle cycling. Their functional status is a critical determinant of androgen-related skin characteristics.