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Depression Neuroendocrine

Meaning

Depression Neuroendocrine refers to the complex interplay between major depressive disorder and dysregulation within the body’s neuroendocrine axes, most notably the Hypothalamic-Pituitary-Adrenal (HPA) axis. This clinical perspective recognizes that imbalances in stress hormones, thyroid hormones, and sex steroids can both contribute to the etiology of depressive symptoms and represent a measurable physiological consequence of the disorder. It highlights the biological underpinnings of mood and the need for comprehensive endocrine evaluation in clinical depression.