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Dendritic Spine Integrity

Meaning

Dendritic Spine Integrity describes the structural soundness, density, and morphological stability of the small, actin-rich protrusions that extend from a neuron’s dendrites, which are the primary postsynaptic sites for excitatory synaptic input. The integrity of these spines is a direct anatomical correlate of synaptic strength and plasticity, fundamentally determining the brain’s capacity for learning and memory formation. Clinical strategies aimed at neuroplasticity often focus on preserving or enhancing the structural health of these microstructures. Loss of integrity is a hallmark of various neurodegenerative and psychiatric conditions.