What is the Origin of Deletion Sequence?

This essential term originates from the field of molecular genetics, which began to elucidate the intricate structure of DNA and the precise mechanism of gene expression in the mid-20th century. The identification of deletion mutations was absolutely critical to deciphering the genetic code and understanding the severe consequences of frameshift errors. The term is fundamentally descriptive of a structural change in the nucleic acid sequence that disrupts the flow of genetic information.

What is the Mechanism of Deletion Sequence?

When a deletion occurs within a protein-coding region, it shifts the three-base codon reading frame for all subsequent amino acids downstream of the mutation. This resulting frameshift mutation typically introduces a premature stop codon, leading to the early termination of protein synthesis. Consequently, the resulting protein, such as a crucial hormone receptor or a key metabolic enzyme, is usually inactive or structurally unstable, severely disrupting the precise signaling required for hormonal regulation and cellular homeostasis.

Deletion Sequence

Meaning

A deletion sequence, within the domain of genetics and molecular biology, is a type of gene mutation characterized by the removal of one or more nucleotide bases from a DNA or RNA molecule. This loss of genetic material fundamentally alters the reading frame of the gene, which frequently results in the production of a truncated, non-functional protein product. Such precise genetic alterations can be either inherited or acquired during a lifetime, contributing directly to the etiology of various endocrine disorders and systemic physiological dysfunction.