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Deimmunization

Meaning

Deimmunization, in the context of therapeutic proteins and peptides, is a sophisticated molecular engineering strategy designed to reduce or eliminate the potential for an administered compound to provoke an adverse immune response in a patient. This process is crucial for long-term hormonal replacement therapies and biologic drug development, particularly when repeated dosing is required. Successful deimmunization minimizes the risk of generating neutralizing antibodies that could negate the treatment’s efficacy or cause hypersensitivity reactions.