A comprehensive, proactive approach to manipulating the underlying molecular and biochemical drivers of biological aging to extend healthspan rather than merely lifespan. This involves addressing hallmarks of aging such as cellular senescence, telomere attrition, and dysregulated nutrient sensing pathways. It is an attempt to optimize the body’s internal biochemical landscape for extended vitality.
Origin
This term originates from the field of geroscience and longevity research, framing aging as a treatable condition characterized by specific chemical dysfunctions. ‘Defy’ implies active resistance against expected physiological decline.
Mechanism
The mechanism centers on modulating core metabolic regulators like AMPK and mTOR to shift the cellular state from growth/proliferation to maintenance/repair, known as hormesis. Targeted interventions might include activating sirtuins or enhancing cellular clearance mechanisms like autophagy. Successfully redefining this chemistry aims to maintain youthful endocrine responsiveness and tissue integrity over time.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.