The consistency and coherence of intrinsic brain activity patterns associated with self-referential thought, internal mentation, and introspection, often quantified via functional magnetic resonance imaging ($text{fMRI}$) connectivity analysis. In the context of hormonal health, stability of the Default Mode Network ($text{DMN}$) is significantly influenced by fluctuating levels of sex steroids and thyroid hormones that act as neuro-regulators. A stable $text{DMN}$ correlates with better emotional regulation and focused internal processing, whereas instability often links to cognitive fragmentation.
Origin
This term originates from cognitive neuroscience, where the $text{DMN}$ was identified as a primary functional network active during rest. “Stability” refers to the temporal correlation and low entropy of the network’s functional connectivity over extended periods of observation. Its inclusion in hormonal science relates directly to the known neurotropic effects of systemic regulators on cortical function.
Mechanism
$text{DMN}$ stability relies on a precise balance of neurotransmitter activity, which is often modulated by steroid receptor signaling within key nodes like the medial prefrontal cortex and posterior cingulate cortex. For example, adequate estrogen levels support robust glutamatergic signaling necessary for strong $text{DMN}$ integration and communication. Hormonal withdrawal or excess can disrupt this delicate balance of excitatory and inhibitory tone, leading to functional desynchronization or hyperconnectivity between the network components.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.