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Deep Sleep Glymphatic System

Meaning

The Deep Sleep Glymphatic System describes the specialized, highly active, sleep-dependent waste clearance pathway operating within the central nervous system, which is dramatically engaged during the slow-wave (deep) stages of sleep. This system leverages the bulk movement of cerebrospinal fluid (CSF) through perivascular channels, actively facilitated by supportive glial cells, to effectively flush accumulated metabolic byproducts, including neurotoxic proteins like amyloid-beta, from the brain parenchyma. Optimal function of this critical system is non-negotiable for maintaining long-term neural health and preventing age-related cognitive decline.