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Deconditioning Syndrome

Meaning

A complex constellation of physiological changes that occur rapidly in the human body due to a significant reduction in physical activity, prolonged bed rest, or chronic sedentary behavior. In the hormonal health domain, this syndrome is characterized by profound metabolic and endocrine shifts, including insulin resistance, loss of muscle mass (sarcopenia), and alterations in the hypothalamic-pituitary-gonadal axis function. It represents a systemic loss of physiological reserve.