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De Novo Neurosteroidogenesis

Meaning

De Novo Neurosteroidogenesis is the biological process describing the synthesis of neurosteroids directly from the precursor molecule cholesterol within the central and peripheral nervous systems. This pathway enables neurons and glial cells, rather than just the classical endocrine glands, to produce these potent steroid hormones locally and on demand. The resulting neurosteroids, such as allopregnanolone and DHEA, act as powerful modulators of neurotransmission, mood, and stress response. This localized production is vital for rapid neuroprotection and synaptic plasticity.