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De Novo Lipogenesis

Meaning

De Novo Lipogenesis (DNL) is the metabolic process by which the body synthesizes fatty acids from non-lipid precursors, primarily excess carbohydrates, in the liver and adipose tissue. This pathway represents a key mechanism for converting surplus dietary glucose or fructose into storable fat. While a normal physiological process, excessive DNL is clinically linked to the development of hepatic steatosis, or fatty liver, and contributes to dyslipidemia and insulin resistance. Its activity is a critical indicator of metabolic inflexibility and chronic positive energy balance.