This refers to the metabolic handling and utilization of ingested nutrients that occurs during the body’s natural nocturnal rest period, a time characterized by lower metabolic activity and altered hormonal profiles. This phase is physiologically less optimal for processing large nutrient loads, particularly carbohydrates, due to the body’s inherent shift towards conservation and repair. It is a critical consideration in chrononutrition and metabolic health, impacting glycemic control.
Origin
This concept is derived from chronobiology, specifically the understanding that the body’s metabolic machinery, or peripheral clocks, is synchronized to the light-dark cycle. The term highlights the physiological reality that nutrient metabolism is time-dependent, with the “dark phase” representing the period of biological night. Processing describes the breakdown and assimilation of food.
Mechanism
During the dark phase, the suprachiasmatic nucleus promotes melatonin secretion and suppresses core body temperature, leading to a state of relative nocturnal insulin resistance in peripheral tissues like muscle and liver. This physiological change reduces the efficiency of glucose disposal, resulting in a prolonged postprandial glucose excursion if food is consumed late. Nutrient processing during this time tends to favor fat storage over immediate energy utilization.
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