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D2 Receptor Sensitivity

Meaning

D2 Receptor Sensitivity refers to the functional responsiveness of the Dopamine Receptor Subtype 2 (D2) located on post-synaptic neurons, particularly within the mesolimbic and nigrostriatal pathways of the brain. Optimal sensitivity is critical for regulating executive function, motivation, reward processing, and prolactin secretion from the pituitary gland. Diminished D2 receptor sensitivity, often a consequence of chronic overstimulation or age-related changes, can manifest clinically as reduced drive, anhedonia, and dysregulated hormonal balance, specifically impacting the prolactin-dopamine axis. Enhancing this sensitivity is a key therapeutic target in neuroendocrinology.