What is the Origin of Cytokine Storm Mitigation?

The term originated in immunology and critical care medicine, particularly in the context of severe infections, but has been adopted in longevity medicine to describe the dangers of chronic, low-grade inflammation, or "inflammaging." Cytokines are small proteins used for cell signaling, and a "storm" describes their detrimental, overwhelming overproduction. Mitigation is the active process of controlling this dangerous overreaction.

What is the Mechanism of Cytokine Storm Mitigation?

Mitigation focuses on re-establishing balance in the immune system and interrupting the positive feedback loops that drive cytokine overproduction. Hormones like cortisol, administered or endogenously regulated, are potent anti-inflammatory agents that can dampen the production of pro-inflammatory cytokines such as IL-6 and TNF-alpha. Furthermore, targeted nutritional and molecular interventions can support the resolution phase of inflammation, promoting a return to immune homeostasis.

Cytokine Storm Mitigation ∞ Area

Cytokine Storm Mitigation

Meaning

This clinical strategy involves therapeutic approaches designed to prevent or reduce an excessive, uncontrolled systemic inflammatory response characterized by the rapid and widespread release of pro-inflammatory cytokines. This hyper-inflammatory state, often triggered by severe physiological stress or infection, can lead to significant tissue damage and multi-organ dysfunction. Mitigation efforts are crucial for preserving physiological integrity and preventing severe systemic pathology.