Skip to main content

Cytokine Signaling Blockade

Meaning

Cytokine signaling blockade is a targeted therapeutic strategy designed to interrupt the pathological cascade of inflammatory signaling mediated by specific protein messengers known as cytokines. In the context of chronic, low-grade systemic inflammation, which is a driver of numerous age-related diseases, this blockade is employed to restore immunological homeostasis. By selectively inhibiting the activity or receptor binding of pro-inflammatory cytokines, clinicians can attenuate chronic immune over-activation. This approach aims to reduce tissue damage and mitigate the inflammatory component of conditions like metabolic syndrome and cardiovascular disease.