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Cytokine-Mediated Suppression

Meaning

Cytokine-mediated suppression describes the process where signaling proteins of the immune system, known as cytokines, actively inhibit or reduce the activity of other cells or physiological processes, often in a regulatory or anti-inflammatory capacity. This biological mechanism is crucial for resolving inflammation and preventing excessive immune responses that could damage host tissues. Within endocrinology, this suppression is particularly relevant as it impacts the synthesis and action of various hormones, creating a critical link between the immune and endocrine systems. Understanding this process is vital for interpreting immune-endocrine imbalances in chronic conditions.