Skip to main content

Cytokine-Induced Resistance

Meaning

A physiological state characterized by a diminished cellular response to the action of specific hormones or growth factors, which is directly triggered or mediated by the sustained presence of inflammatory signaling molecules known as cytokines. This resistance is a key link between chronic low-grade inflammation and metabolic dysregulation, often seen in conditions like insulin resistance or leptin resistance. Understanding this phenomenon is vital for addressing the root causes of many age-related endocrine disorders.