What is the Origin of Cytokine-Induced Disruption?

The term combines 'cytokine,' derived from the Greek cyto- (cell) and kinos (movement), with 'disruption,' highlighting the interference with established biological order. Its clinical relevance lies in the intersection of immunology and endocrinology, recognizing chronic, low-grade inflammation as a major driver of age-related hormonal decline and disease.

What is the Mechanism of Cytokine-Induced Disruption?

Pro-inflammatory cytokines, such as Interleukin-6 and Tumor Necrosis Factor-alpha, can directly inhibit the pulsatile release of GnRH from the hypothalamus, thereby suppressing the entire gonadal axis and reducing sex hormone production. They also impair insulin receptor sensitivity in peripheral tissues, leading to insulin resistance, and can cross the blood-brain barrier to disrupt neurotransmitter balance and mood regulation.

Cytokine-Induced Disruption ∞ Area

Cytokine-Induced Disruption

Meaning

Cytokine-induced disruption refers to the detrimental impact on normal physiological processes, particularly endocrine signaling, caused by excessive or chronic inflammatory cytokine release. These signaling proteins, typically involved in immune response, can interfere with hormone synthesis, transport, receptor binding, and central nervous system regulation. This inflammatory interference is a significant factor in the development of hormonal resistance and metabolic dysfunction.