What is the Origin of Cytochrome P450arom?

The term is a compound name: "Cytochrome P450" refers to a large family of heme-containing monooxygenases, first named for their characteristic light absorption at 450 nanometers when bound to carbon monoxide. The suffix "arom" is an abbreviation for aromatase, derived from the chemical process of aromatization, which converts the non-aromatic A-ring of an androgen molecule into the aromatic A-ring characteristic of estrogens.

What is the Mechanism of Cytochrome P450arom?

The enzyme catalyzes the three sequential hydroxylation steps required to convert androgens, such as testosterone and androstenedione, into their respective estrogenic counterparts, estradiol and estrone. This reaction involves the removal of a methyl group and the creation of a phenolic A-ring, a process that requires molecular oxygen and NADPH. Clinically, inhibitors of this enzyme are used to reduce estrogen levels, particularly in estrogen-receptor-positive breast cancer, by blocking this crucial conversion pathway.

Cytochrome P450arom ∞ Area

Cytochrome P450arom

Meaning

Cytochrome P450arom, scientifically known as Aromatase, is a critical enzyme responsible for the final and rate-limiting step in the biosynthesis of estrogens from androgens. This enzyme is a member of the Cytochrome P450 superfamily and is ubiquitously expressed in various tissues, including the ovaries, testes, adipose tissue, brain, and bone. Its activity directly determines the circulating levels of estrogens like estradiol, making it a pivotal target in both hormonal therapy and cancer treatment.