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Cytochrome P450 Inhibition

Meaning

Cytochrome P450 (CYP) inhibition is a drug-drug or drug-nutrient interaction where a substance decreases the metabolic activity of one or more enzymes in the CYP450 family. These enzymes are primarily responsible for the biotransformation and clearance of endogenous compounds, including hormones, and exogenous substances like medications. Inhibition can lead to elevated plasma concentrations of co-administered drugs or hormones, potentially causing toxicity or enhanced therapeutic effects.