What is the Origin of Cytochrome B5 Reductase 3?

The name is derived from the enzyme's function and chemical components: "Cytochrome" refers to the heme-containing protein it interacts with; "B5 Reductase" denotes its action as a reducing enzyme for cytochrome b5; and "3" specifies the particular isoform. It is a fundamental component of the human enzymatic and hormonal synthesis machinery.

What is the Mechanism of Cytochrome B5 Reductase 3?

CYB5R3 catalyzes the transfer of electrons from NADH to cytochrome b5, which is necessary for the activity of several desaturase and hydroxylase enzymes. In the context of hormonal health, this reductive power is vital for the activity of 17beta-hydroxysteroid dehydrogenase, an enzyme responsible for converting androstenedione to testosterone and estrone to estradiol, directly impacting the circulating levels of these sex hormones.

Cytochrome B5 Reductase 3 ∞ Area

Cytochrome B5 Reductase 3

Meaning

Cytochrome B5 Reductase 3 (CYB5R3) is an enzyme that plays a crucial role in various metabolic pathways, notably the reduction of cytochrome b5. Clinically, this enzyme is significant in the biosynthesis and metabolism of cholesterol, fatty acids, and steroid hormones, including estradiol and testosterone. Its function is essential for maintaining the proper redox state in the endoplasmic reticulum and outer mitochondrial membrane.