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CYP450 Enzymes

Meaning

Cytochrome P450 enzymes, commonly referred to as CYP450 enzymes, represent a large superfamily of heme-containing monooxygenases primarily located in the liver and small intestine, playing a pivotal role in xenobiotic and endogenous metabolism. These enzymes are critical for the biotransformation of both endogenous compounds, including steroid hormones and fatty acids, and exogenous substances like pharmaceuticals and environmental toxins. Genetic polymorphisms in these enzymes can significantly alter an individual’s capacity to metabolize hormones and medications, affecting treatment efficacy.