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CYP2D6 Polymorphisms

Meaning

CYP2D6 polymorphisms refer to common genetic variations, or different forms, found in the cytochrome P450 2D6 enzyme gene, which is critical for metabolizing approximately 25% of all clinically used drugs, including certain psychoactive medications that indirectly affect hormonal balance. These genetic differences dictate the rate at which an individual metabolizes these substrates, leading to classifications such as poor, intermediate, extensive, or ultrarapid metabolizers. Understanding an individual’s CYP2D6 genotype is paramount in pharmacogenomics to predict drug efficacy and potential toxicity, particularly when prescribing medications that may influence neuroendocrine pathways or sex hormone metabolism. The resulting variation directly impacts the effective dose required for therapeutic benefit in personalized wellness protocols.