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CYP2D6 Genotype

Meaning

The CYP2D6 Genotype refers to the specific genetic makeup of the Cytochrome P450 2D6 enzyme gene, which is a primary determinant of an individual’s capacity to metabolize a substantial number of clinically relevant medications, including certain psychotropics and hormonal agents like tamoxifen. This specific genetic profile classifies individuals into distinct metabolizer phenotypes, ranging from poor to ultrarapid, which dictates the rate of drug clearance and active metabolite formation. Understanding this genotype is critical for personalized medicine to optimize drug dosing and mitigate adverse effects.