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CYP2C9

Meaning

CYP2C9 refers to Cytochrome P450 2C9, a pivotal enzyme primarily located in the liver that belongs to the Cytochrome P450 superfamily of monooxygenases. This enzyme is essential for Phase I metabolism, which involves oxidizing both xenobiotics, such as therapeutic drugs, and numerous endogenous compounds. In the domain of hormonal health, CYP2C9 plays a direct role in the breakdown and clearance of various steroid hormones and fatty acids. Genetic polymorphisms in the CYP2C9 gene can significantly alter the enzyme’s metabolic capacity, necessitating personalized clinical dosing strategies for many medications.