Skip to main content

CYP2A6 Metabolism

Meaning

The enzymatic biotransformation process primarily executed by the Cytochrome P450 2A6 enzyme, a key hepatic monooxygenase responsible for metabolizing a variety of xenobiotics, most notably nicotine and its primary metabolite, cotinine. This metabolic pathway is central to determining an individual’s rate of nicotine clearance, which directly influences addiction severity, smoking behavior, and the required dosage for nicotine replacement therapy. Understanding the functional status of this enzyme is crucial for personalized addiction treatment and assessing toxicological burden.