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CYP26B1

Meaning

CYP26B1 is a specific enzyme belonging to the cytochrome P450 superfamily, which functions as a key metabolic regulator responsible for the catabolism of retinoic acid, a biologically active metabolite of vitamin A. This enzyme is highly expressed in various crucial tissues, including the central nervous system, bone, and reproductive organs, where it maintains precise local concentrations of retinoic acid. Retinoic acid is a potent signaling molecule that acts as a ligand for nuclear receptors, profoundly influencing gene expression related to cellular differentiation, tissue homeostasis, and embryonic development. The enzyme’s activity is therefore critical for tightly regulating the delicate balance of this vital signaling pathway.