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CYP1A1 Polymorphism

Meaning

CYP1A1 polymorphism denotes a common variation in the gene encoding the Cytochrome P450 1A1 enzyme, a critical hepatic enzyme involved in the phase I metabolism of xenobiotics and endogenous compounds, including estrogen. These genetic variations, or single nucleotide polymorphisms (SNPs), can alter the enzyme’s activity, affecting the rate and pathway by which the body processes and detoxifies hormones. Individuals with specific CYP1A1 variants may exhibit an altered balance of estrogen metabolites, which has implications for tissue health and hormonal cancer risk. Personalized medicine relies on identifying these polymorphisms to optimize therapeutic strategies.