What is the Origin of CYP1A1 Enzyme?

The designation Cytochrome P450 1A1 reflects its classification within the heme-containing monooxygenase family, specifically the first subfamily (1) and the first member (A1). Its study originated in toxicology but gained relevance in hormonal health due to its interaction with aryl hydrocarbon receptors. This enzyme links environmental exposure to hormonal modulation.

What is the Mechanism of CYP1A1 Enzyme?

The enzyme catalyzes the hydroxylation of various substrates, often activating procarcinogens or altering the balance between active and inactive estrogen metabolites. Upregulation of CYP1A1, often induced by environmental toxins, can shift estrogen metabolism toward potentially more proliferative forms, thereby influencing downstream cellular responses in hormone-sensitive tissues.

CYP1A1 Enzyme ∞ Area

CYP1A1 Enzyme

Meaning

CYP1A1 Enzyme refers to a specific member of the Cytochrome P450 superfamily, predominantly involved in the Phase I biotransformation of endogenous compounds and exogenous xenobiotics. Clinically, its activity is significant because it metabolizes planar aromatic hydrocarbons and can influence the metabolism of certain estrogens. Its presence and activity are indicators of detoxification system load.