What is the Origin of CYP19A1?

The nomenclature CYP19A1 is a systematic designation used in genetics and biochemistry. "CYP" stands for Cytochrome P450, a large group of enzymes involved in various metabolic processes. The numbers and letters following denote the family, subfamily, and specific gene, reflecting its place in the established enzyme classification system.

What is the Mechanism of CYP19A1?

The aromatization process occurs in various tissues, including the ovaries, testes, adipose tissue, brain, and bone. The enzyme requires molecular oxygen and NADPH to perform the three sequential hydroxylation steps that convert the C19 androgens into C18 estrogens. Genetic polymorphisms in the CYP19A1 gene or its transcriptional regulation can alter enzyme activity, leading to variations in estrogen metabolism and potentially impacting hormonal balance, reproductive function, and bone density.

CYP19A1 ∞ Area

CYP19A1

Meaning

CYP19A1 is the official gene symbol for the human enzyme Aromatase, a member of the cytochrome P450 superfamily, which catalyzes the final and rate-limiting step in the biosynthesis of estrogens. This crucial enzyme converts androgens, specifically testosterone and androstenedione, into the corresponding estrogens, estradiol and estrone. The activity of CYP19A1 is a major determinant of circulating estrogen levels in both males and females.

A female subject embodies vibrant optimal health, indicative of successful hormone optimization and metabolic health. Her serene expression reflects achieved endocrine balance, physiological regulation, and improved cellular function via personalized treatment for clinical wellness outcomes.

How Do Genetic Factors Influence an Individual’s Response to Lifestyle Interventions for Estradiol Regulation?

Genetic variations profoundly calibrate individual estradiol responses to lifestyle, necessitating personalized wellness protocols for optimal endocrine balance.

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HRTioAugust 29, 2025

CYP19A1

Meaning

Origin

Mechanism

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