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Cutaneous Steroidogenesis

Meaning

The intrinsic biochemical process of synthesizing steroid hormones, including glucocorticoids, mineralocorticoids, and sex steroids, directly within the layers of the skin, known as the cutis. This localized, peripheral production functions as an autocrine or paracrine system, meaning the hormones primarily affect the skin cells themselves or adjacent cells, operating largely independent of systemic endocrine gland control. This peripheral hormone synthesis plays a critical and protective role in maintaining skin barrier function, local immunity, and overall dermatological homeostasis.