The interdisciplinary field of study investigating the complex bidirectional communication and functional integration between the skin’s cellular components and the neuroendocrine system, involving locally synthesized hormones, neuropeptides, and neurotransmitters. This field explores how the skin acts not only as a target organ for systemic hormones but also as a peripheral neuroendocrine organ capable of producing and responding to its own regulatory molecules. It provides a comprehensive understanding of the skin’s dynamic role in maintaining local and systemic homeostasis.
Origin
This term is a fusion of “cutaneous” (relating to the skin), “neuro-” (referring to the nervous system), and “endocrinology” (the study of hormones and glands). Its origin lies at the intersection of dermatology, neuroscience, and endocrinology, emerging as scientists recognized the skin’s capacity for complex signaling beyond simple barrier function. The nomenclature reflects the sophisticated biological overlap between these regulatory systems.
Mechanism
Skin cells, including keratinocytes, melanocytes, and fibroblasts, possess receptors for and can locally produce classical hormones like glucocorticoids, androgens, and estrogens, alongside neuropeptides such as substance P and calcitonin gene-related peptide (CGRP). These locally produced and systemically delivered signals regulate crucial skin functions, including inflammation, pigmentation, hair growth cycles, and wound repair. This intricate communication network allows the skin to rapidly adapt to internal and external environmental changes.
We use cookies to personalize content and marketing, and to analyze our traffic. This helps us maintain the quality of our free resources. manage your preferences below.
Detailed Cookie Preferences
This helps support our free resources through personalized marketing efforts and promotions.
Analytics cookies help us understand how visitors interact with our website, improving user experience and website performance.
Personalization cookies enable us to customize the content and features of our site based on your interactions, offering a more tailored experience.