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Critical Window Hypothesis

Meaning

The Critical Window Hypothesis, in the context of hormonal health, posits that there are specific, time-sensitive periods in a person’s life where therapeutic intervention, particularly with hormone replacement therapy, yields the maximum clinical benefit and minimizes potential risk. This concept suggests that initiating therapy too long after the onset of hormonal deficiency, such as the menopausal transition, may be less effective in preventing long-term sequelae. The hypothesis emphasizes the clinical importance of timely diagnosis and therapeutic initiation for achieving optimal long-term health outcomes.