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Critical Period Hypothesis

Meaning

The Critical Period Hypothesis proposes that there are specific, limited developmental windows during which the neuroendocrine system exhibits maximal sensitivity to external and internal hormonal stimuli. Exposure to certain factors, or the lack thereof, during these restricted periods can induce permanent, structural, and functional changes in hormonal axes and neural circuitry. This concept underscores the profound impact of in utero and early postnatal environments on programming lifelong metabolic, behavioral, and hormonal disease risk. Understanding these critical windows is paramount for designing effective preventative health and longevity interventions.