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COX-2 Inhibition

Meaning

COX-2 Inhibition is a pharmacological strategy that selectively blocks the activity of the Cyclooxygenase-2 enzyme, aiming to reduce inflammation and pain without significantly impacting the protective functions mediated by the related COX-1 enzyme. Cyclooxygenase enzymes catalyze the conversion of arachidonic acid into prostaglandins, which are potent mediators of inflammatory and pain responses throughout the body. This targeted inhibition is often sought to mitigate the gastrointestinal side effects commonly associated with non-selective anti-inflammatory agents.