What is the Origin of Cortisol to DHEA-S Ratio?

This metric originates from the field of adrenal function testing, specifically assessing the output of the adrenal cortex along the pregnenolone steal pathway. It provides a more nuanced view of adrenal health than measuring either hormone in isolation.

What is the Mechanism of Cortisol to DHEA-S Ratio?

DHEA-S acts as a precursor for sex hormones and possesses mild anabolic properties, often counterbalancing cortisol's catabolic effects on tissue breakdown and glucose mobilization. When chronic HPA axis activation favors cortisol production at the expense of DHEA-S synthesis, the ratio shifts, signaling a state where tissue preservation is compromised. Optimization seeks to normalize this endocrine dynamic.

Cortisol to DHEA-S Ratio

Meaning

The Cortisol to DHEA-S Ratio is a quantitative biomarker derived from salivary or serum analysis, representing the relative balance between the primary catabolic glucocorticoid (Cortisol) and the precursor adrenal androgen (DHEA-S). This ratio serves as an indicator of adrenal stress load and the overall capacity for anabolic vs. catabolic processes within the endocrine system. An elevated ratio suggests chronic stress overwhelming adaptive capacity.

$A fractured branch displays raw wood, representing hormonal imbalance and metabolic dysfunction. Resilient lichen and moss signify cellular repair and endocrine recovery, illustrating the patient journey towards hormone optimization.$