A targeted therapeutic intervention designed to restore the normal circadian rhythm of cortisol secretion, specifically addressing patterns of dysregulation such as a flattened curve, elevated nighttime levels, or a blunted morning rise. This correction is essential because the natural diurnal pattern of cortisol is crucial for regulating sleep-wake cycles, energy metabolism, and immune function. The objective is to optimize the Hypothalamic-Pituitary-Adrenal (HPA) axis function for improved stress resilience and overall vitality.
Origin
This is a clinical term derived from the key stress hormone cortisol and the physiological concept of timing within the circadian system, combined with correction, indicating a therapeutic adjustment. It speaks directly to the clinical utility of chronobiology in endocrinology.
Mechanism
Correction often involves strategic use of lifestyle modifications, targeted nutritional support, and adaptogenic compounds to modulate the adrenal glands’ response to ACTH and the central drive from the hypothalamus and pituitary. By influencing neurotransmitter balance and HPA axis sensitivity, the intervention seeks to re-establish the correct amplitude and phase of the cortisol curve, promoting a robust morning peak for energy and a low evening trough for restorative sleep.
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