What is the Origin of Cortisol Suppression Sequence?

The concept is central to endocrinology, specifically the feedback inhibition within the HPA axis where elevated cortisol acts on the hypothalamus and pituitary. Suppression is the natural resolution phase following the initial stimulus. Understanding this sequence allows us to evaluate the dynamic responsiveness of the adrenal axis.

What is the Mechanism of Cortisol Suppression Sequence?

Once cortisol reaches sufficient plasma concentrations, it binds to glucocorticoid receptors in the hypothalamus (inhibiting CRH) and the pituitary (inhibiting ACTH release). This reduction in trophic signals leads to decreased stimulation of the adrenal cortex, thereby lowering subsequent cortisol output. Nutritional status and sleep quality critically modulate the sensitivity of these feedback receptors, influencing the sequence's efficiency.

Cortisol Suppression Sequence ∞ Area

Cortisol Suppression Sequence

Meaning

This sequence describes the regulated, negative feedback loop designed to decrease circulating cortisol levels after a period of activation, often following an acute stressor or morning rise. Effective suppression is a hallmark of a well-functioning HPA axis, signaling homeostasis has been restored. Failure in this sequence results in prolonged glucocorticoid exposure, which detrimentally impacts insulin signaling and anabolic processes. It represents the ‘off-switch’ of the stress response.