What is the Origin of Cortisol Sequencing?

The term is a clinical application of chronobiology and endocrinology, combining "cortisol" with "sequencing" to denote the temporal ordering of measurements. This approach emerged from the realization that the pattern of hormone release is often more clinically significant than any single static concentration. It is a refinement of the standard diurnal variation assessment, providing actionable kinetic data.

What is the Mechanism of Cortisol Sequencing?

The process involves collecting biological samples, typically saliva or dried urine, at defined intervals, such as waking, midday, evening, and before bed. Analyzing these timed samples allows clinicians to plot the cortisol awakening response and the evening decline. This detailed kinetic data reveals whether the body's stress response system is appropriately ramping up and winding down in sync with the circadian cycle. Dysfunctional sequencing guides targeted adrenal support.

Cortisol Sequencing ∞ Area

Cortisol Sequencing

Meaning

Cortisol Sequencing refers to the precise measurement of cortisol levels at multiple, specific time points throughout the day to map the complete diurnal rhythm. This diagnostic technique moves beyond a single morning measurement to capture the dynamic release and clearance pattern of the stress hormone. Accurate sequencing is crucial for identifying subtle patterns of HPA axis dysregulation that impact energy, sleep, and immune function. The resulting curve is highly individualized.