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Cortisol Sensitivity Genotyping

Meaning

Cortisol Sensitivity Genotyping is a molecular diagnostic procedure that analyzes specific genetic markers to predict an individual’s cellular responsiveness to the stress hormone cortisol. The test identifies polymorphisms, particularly in the glucocorticoid receptor gene (NR3C1), that influence the efficiency of cortisol binding and the resulting downstream gene transcription. This information is clinically invaluable for understanding an individual’s unique physiological stress tolerance and for tailoring effective HPA axis support protocols. It offers a precise, foundational insight into the metabolic and immune effects of chronic stress.