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Cortisol Rhythmicity Buffering

Meaning

Cortisol Rhythmicity Buffering is the physiological and clinical process of stabilizing the naturally occurring diurnal rhythm of cortisol, which is characterized by a sharp morning rise and a gradual decline throughout the day, in the face of chronic or acute stressors. Buffering aims to prevent both excessive hyper- or hypo-cortisolism, which can arise from chronic systemic stress, thereby preserving the structural and functional integrity of the hypothalamic-pituitary-adrenal (HPA) axis. This is a key therapeutic strategy for maintaining adrenal health and promoting effective stress adaptation.